Compile Data Set for Download or QSAR
Found 64 from Osaka University of Pharmaceutical Sciences
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)copy SMILEScopy InChI
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494136(CHEMBL2441945)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494138(CHEMBL2441946)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494137(CHEMBL2441942)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494132(CHEMBL2441941)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494141(CHEMBL2441940)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494127(CHEMBL2441944)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494135(CHEMBL2441933)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16499((2S)-2-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16500((2S)-2-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16502((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(benzylcarbamoyl)oxi...)copy SMILEScopy InChI
Affinity DataIC50: 29nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494131(CHEMBL2441943)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494139(CHEMBL2441938)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)copy SMILEScopy InChI
Affinity DataIC50: 38nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16510((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494142(CHEMBL2441935)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16508((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)copy SMILEScopy InChI
Affinity DataIC50: 120nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PGNPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494129(CHEMBL2441948)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494130(CHEMBL2441947)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494128(CHEMBL2441939)copy SMILEScopy InChI
Affinity DataIC50: 316nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494126(CHEMBL2441949)copy SMILEScopy InChI
Affinity DataIC50: 316nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16501((2S)-2-[(2S,3R)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)copy SMILEScopy InChI
Affinity DataIC50: 410nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494134(CHEMBL2441936)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494140(CHEMBL2441934)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50483937(CHEMBL1783813)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50483935(CHEMBL1783812)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474910(CHEMBL189836)copy SMILEScopy InChI
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BDQPubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50483932(Betulin 3,28-Diacetate | Betulin Diacetate)copy SMILEScopy InChI
Affinity DataIC50: 2.65E+3nMAssay Description:Antiviral activity against HIV1 Reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50483934(24-Methylenecycloartanol Ferulate | 24-Methylenecy...)copy SMILEScopy InChI
Affinity DataIC50: 3.07E+3nMAssay Description:Antiviral activity against HIV1 Reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50483936(3-O-Ferulylcycloartenol | Cycloartenol Ferulate | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.64E+3nMAssay Description:Antiviral activity against HIV1 Reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM23208((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50483933(CHEMBL1783816 | Karounidiol 29-Benzoate)copy SMILEScopy InChI
Affinity DataIC50: 4.03E+3nMAssay Description:Antiviral activity against HIV1 Reverse transcriptase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50241944(CHEMBL486393 | Lupenone | lupeone)copy SMILEScopy InChI
Affinity DataIC50: 4.94E+3nMAssay Description:Antiviral activity against HIV1 Reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50494133(CHEMBL2441937)copy SMILEScopy InChI
Affinity DataIC50: 6.31E+3nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R78J5RPubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086856PubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16504(CA inhibitor 7 | CA073 | PrNH-tES-Ile-Pro-OBzl | b...)copy SMILEScopy InChI
Affinity DataIC50: 9.10E+3nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50377927(Clerodol | Fagarasterol | Farganasterol | LUPEOL |...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16506((2S)-1-(2-{[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 1.53E+4nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PGNPubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260250(CHEMBL491188 | Olean-12-en-3beta,15alpha-diol)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474907(CHEMBL193251)copy SMILEScopy InChI
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BDQPubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474904(CHEMBL191216)copy SMILEScopy InChI
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BDQPubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474909(CHEMBL189793)copy SMILEScopy InChI
Affinity DataIC50: 2.38E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BDQPubMed
TargetCathepsin B(Bos taurus (bovine))
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16497((2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+4nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM23207((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-5-(hydroxymet...)copy SMILEScopy InChI
Affinity DataIC50: 3.86E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260252(CHEMBL489552 | olean-12-en-3bea,15alpha,24-triol)copy SMILEScopy InChI
Affinity DataIC50: 3.87E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X92C63PubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50250882((23R,25R)-3,4-seco-9beta-H-lanosta-4(28),7-dien-26...)copy SMILEScopy InChI
Affinity DataIC50: 4.26E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8RMHPubMed
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